What are the alkaloids in kratom, and what do they do?

Are you searching all over the places for the kratom alkaloids? What are they, and how do they work out to provide such miraculous results? High five! That’s where you have to be!

It’s true that many kratom enthusiasts, who have been taking kratom for years and years still do not know what brings out the entire effect. You must have noticed that little toddlers are concerned about eating chocolate, but they don’t know how chocolate is making them happy?

Similar is the case here; we know that kratom can help us with our daily stressors, boosting our mood, and providing relaxation. Moreover, it can be your best buddy that can help to withdraw from opioids, but you don’t know what the hidden mechanisms are.

Yes, you are guessing pretty right, the game is all about the KRATOM ALKALOIDS.

This article is going to shoot the breeze at EVERYTHING that you must know about the kratom alkaloids. Let’s see what is there to unfold!

What are alkaloids?

First, it is essential to guide you with this concept. Alkaloids are the nitrogenous compounds in the plant, responsible for “defense” against various threats. Just like the anti-bodies protect us against flu, sore throat, fever, etc.

How can alkaloids help you?

Alkaloids produce strong bodily effects upon ingestion. It is not necessary to take higher doses of a particular alkaloid to produce the desired result.

They can work on minimum doses as well, depending upon their properties. Following are the effects an alkaloid may create in your body depending upon its nature:

  • Relaxing
  • Mood-boosting
  • Anti-inflammatory
  • Euphoria
  • Anti-anxiety
  • Pain reduction, etc.

These effects are highly dependent upon the concentration of specific alkaloids in the plant.

There are a plethora of studies carried out on the potency and diversity of different alkaloids and how they can be used to form the drugs to assist in numerous ways.

For instance, if you have been tired lately and have to prepare for an exam overnight, a cup of coffee can do wonders. How? Because the alkaloid caffeine present in the coffee beans will stimulate your nervous system. As a result, you will feel fresh and focused.

Animals are also comparable to the plants in this case. Some pieces of evidence suggest the presence of alkaloids in the animals too.

Red Elephant Kratom


Leading Alkaloids in Kratom

Kratom is well-known for treating many conditions, from pain-killing effect to anti-depressing effect, it has come far away. Do you know about the responsible factor for its fame? IT’S ALKALOID CONTENT!

The two prominent alkaloids of kratom, Mitragynine, and 7-Hydroxy-Mitragynine, bring about most of the effects once ingested.


 The alkaloid content of kratom comprises 66% of Mitragynine, that’s pretty huge. No? But various factors can influence the Mitragynine concentration, like at what time you have harvested kratom, what were the optimal growing environments, what strain of kratom you are considering, etc.

According to kratom’s drug profile, there are different Mitragynine concentrations in different strains. White vein kratom, green vein kratom, and Thai strains have the highest concentrations of Mitragynine alkaloid, while Malaysian strains of kratom have the lowest levels of Mitragynine concentrations.

Effects of Mitragynine Alkaloid: The impacts of Mitragynine may vary a bit from one person to another because everyone differs upon sensitivity; collective results are:

  • Anti-Diarrheal
  • Anti-Malarial
  • Cough-suppressant
  • Stimulating
  • Anti-Depressant

Note: At higher doses, the effects are more pain-killing and relaxing. While at lower dosages, it has more stimulating effects.

The Half-life of Mitragynine Alkaloid: A 2015 study claims that the half-life of Mitragynine alkaloid of kratom is 23.24 ± 16.07 hrs. This value indicates that half of the Mitragynine alkaloids will leave the body after 23.24 hours.

Although this mechanism is not standard for all, there are exceptions related to metabolism rates and certain enzymes.


The 7-Hydroxy-Mitragynine makes up 2% of the total alkaloid content in kratom leaves.

Although it acts in a smaller area but has a significant influence. For this reason, many vendors are manufacturing tinctures of kratom consisting of 7-Hydroxy-Mitragynine alkaloids.

Red vein kratom strains have high concentrations of 7-Hydroxy-Mitragynine alkaloids, especially Red Vein Maeng Da.

Effects of 7-Hydroxy-Mitragynine:

Like Mitragynine, the impact of 7-Hydroxy-Mitragynine also varies from person to person. It has high potency levels as compared to Mitragynine, which means, upon ingesting even small doses, you will see winning results. Have a look at the effects given below:

  • Pain-relieving
  • Cough-Suppressant
  • Anti-Diarrheal
  • Stimulating

The Half-life of 7-Hydroxy-Mitragynine: According to research, 7-Hydroxy-Mitragynine has a half-life of 2.5 ± .7 hours, half of the alkaloid content will leave the body after 2.5 hours. For this reason, many people have to take smaller doses more often during the day for relieving pain.

Other Alkaloids of Kratom

There are 26 other kratom alkaloids but are not potent enough to carry out the effects like Mitragynine and 7-Hroxy-Mitragynine. Paynantheine alkaloid is present in 8.6%-9%, and Speciogynine alkaloid is around 6.6%-7%.

Although there is very little research available, they tend to be muscle relaxant once ingested.

The other 24 alkaloids are in negligible amounts and are less active.

The Hidden mechanism behind alkaloid formation

Alkaloids are formed in plants when they are at the initial stages of development and are more vulnerable to specific changes as compared to a fully grown plant. Alkaloids have connections with particular gene pathways.

Anything that will influence these pathways will consequently affect alkaloid production, like soil, temperature, light exposure, etc.

When multiple gene pathways interact with each other to produce alkaloids. Remember, different pathways have different effects on every plant.

How to Increase Alkaloid concentrations in Kratom Plant?

Follow the tips mentioned below to get a massive amount of alkaloid content in your kratom plant:

  • Provide the right amount of nitrogen to your kratom plant, especially in initial stages.
  • Don’t forget about sunlight, as it will carry out the significant chemical reactions.
  • Add bacteria in the soil.
  • Make sure the land has a considerable amount of salts.
  • Carbon dioxide also proves to be helpful.

In A Nut-Shell

Alkaloids are the backbone of the kratom plant. You should follow the critical factors for alkaloid production for desired effects. Kratom alkaloids are not ordinary ones, so every other person is adding kratom to their health regime.

Ultra Green Entikong Kratom